{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐675, a microRNA processed from the first exon of the imprinted long noncoding RNA H19, has emerged as a critical regulatory molecule in cancer. In colorectal cancer, for example, miR‐675 is up‐regulated and promotes tumorigenesis by directly targeting and downregulating the tumor suppressor retinoblastoma protein (RB)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Conversely, in prostate cancer, diminished H19/miR‐675 levels have been associated with malignant progression, with restoration of miR‐675 levels reducing cell migration through the repression of transforming growth factor β–induced protein (TGFBI)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Elevated levels of miR‐675 have also been documented in gliomas, where it promotes tumor invasion by modulating Cadherin 13 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", in gastric cancer where miR‐675 targets the tumor suppressor RUNX1 to enhance cell proliferation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and in aggressive breast cancers, where its up‐regulation drives an invasive phenotype via downregulation of ubiquitin ligases that normally restrict receptor tyrosine kinase signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In bladder cancer, miR‐675 overexpression contributes to abnormal cell proliferation by interfering with p53 activation and perturbing apoptotic regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similar oncogenic roles have been observed in non–small cell lung and head and neck cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and additional studies in gastric and liver cancers have further implicated miR‐675 in promoting malignant phenotypes by modulating key signaling pathways such as AKT/mTOR and by affecting cell cycle regulators."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": " Furthermore, in glioma a direct targeting of the retinoblastoma gene (RB1) by miR‐675 was demonstrated to enhance proliferative and invasive capacities"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while exosomal transfer of miR‐675 has been linked to the metastatic behavior of osteosarcoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In plasma from breast cancer patients, correlations between circulating H19 and miR‐675 further underscore its potential as a diagnostic marker, and the identification of competing endogenous RNAs (such as circKDM4B) that sponge miR‐675 highlights its significance in modulating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, miR‐675 exerts its regulatory effects by targeting a spectrum of molecules that modulate key signaling networks. In gastric cancer, beyond RUNX1, miR‐675 has been shown to facilitate malignant behavior by enhancing the AKT/mTOR pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " It can also destabilize epithelial integrity by directly binding the 3′‐untranslated regions of tight junction and adherens junction proteins—such as ZO‐1 and E‐cadherin—thereby compromising intestinal barrier function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " In the context of cell fate and differentiation, miR‐675 targets histone deacetylases 4–6 to modulate adipogenic commitment of bone marrow mesenchymal stem cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ", and it directly binds to the 3′‐UTR of MITF in keratinocytes to influence melanogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Moreover, alterations in p53 signaling observed in liver cancer and hepatocyte injury have been linked to elevated miR‐675 levels"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ", while in HBV‐associated liver injury and diabetic nephropathy the H19/miR‐675 axis modulates PPARα and the vitamin D receptor/EGR1 pathway to impact cell survival and energy metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in tumorigenesis, miR‐675 is integral to several physiological and developmental processes. During osteoblast differentiation, up‐regulation of H19 and miR‐675 promotes osteogenesis by inhibiting transforming growth factor–β1 (TGF‐β1) signaling and subsequent Smad3 phosphorylation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ", while in articular chondrocytes, miR‐675—under the transcriptional control of SOX9—enhances COL2A1 expression and cartilage matrix production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": " In the placenta, reduced expression of H19/miR‐675 has been associated with aberrant trophoblast proliferation in preeclampsia due to deregulated NOMO1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Furthermore, miR‐675 has been harnessed in therapeutic strategies, as illustrated by its ability to inhibit DUX4 expression in facioscapulohumeral muscular dystrophy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": ", and its chondroprotective, anti‐apoptotic effects in osteoarthritis models underscore its potential in regenerative medicine."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wing Pui Tsang, Enders K O Ng, Simon S M Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgp181"}], "href": "https://doi.org/10.1093/carcin/bgp181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19926638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19926638"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miaojun Zhu, Qin Chen, Xin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.12902"}], "href": "https://doi.org/10.1111/febs.12902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24988946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24988946"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Shi, Yingyi Wang, Wenkang Luan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0086295"}], "href": "https://doi.org/10.1371/journal.pone.0086295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24466011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24466011"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ming Zhuang, Wen Gao, Jing Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.12.126"}], "href": "https://doi.org/10.1016/j.bbrc.2013.12.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24388988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24388988"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Constance Vennin, Nathalie Spruyt, Fatima Dahmani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4976"}], "href": "https://doi.org/10.18632/oncotarget.4976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26353930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26353930"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Changkun Liu, Zhouguang Chen, Jianzheng Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3779-2"}], "href": "https://doi.org/10.1007/s13277-015-3779-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26198047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26198047"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dan He, Jun Wang, Chunfang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-015-0342-0"}], "href": "https://doi.org/10.1186/s12943-015-0342-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25889562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25889562"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Guo-Fang Guan, De-Jun Zhang, Lian-Ji Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.16571"}], "href": "https://doi.org/10.7150/ijms.16571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27994496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27994496"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zi-Hui Zheng, Dong-Mei Wu, Shao-Hua Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-675-5p induced by lncRNA H19 was associated with tumor progression and development by targeting tumor suppressor p53 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29182"}], "href": "https://doi.org/10.1002/jcb.29182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31219199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31219199"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lei Liu, Yan-Chun Tian, Gang Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-675 is frequently overexpressed in gastric cancer and enhances cell proliferation and invasion via targeting a potent anti-tumor gene PITX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2019.109352"}], "href": "https://doi.org/10.1016/j.cellsig.2019.109352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31260797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31260797"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jue Wang, Youli Zhang, Hong Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mir-675-5p regulates the progression and development of pancreatic cancer via the UBQLN1-ZEB1-mir200 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15330"}], "href": "https://doi.org/10.18632/oncotarget.15330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28212565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28212565"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yongzi Xu, Yanhui Liu, Zhenrong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA H19 is involved in sorafenib resistance in hepatocellular carcinoma by upregulating miR‑675."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7608"}], "href": "https://doi.org/10.3892/or.2020.7608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32627034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32627034"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yungui Zheng, Xiaowen Lu, Liepeng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2017.09.006"}], "href": "https://doi.org/10.1016/j.humpath.2017.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28970140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28970140"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Liangzhi Gong, Qiyuan Bao, Chuanzhen Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.016"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29626470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29626470"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Volkmar Müller, Leticia Oliveira-Ferrer, Bettina Steinbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interplay of lncRNA H19/miR-675 and lncRNA NEAT1/miR-204 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12472"}], "href": "https://doi.org/10.1002/1878-0261.12472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30803129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30803129"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zongcai Liu, Fen Ning, Yanna Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Commun (Lond) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cac2.12117"}], "href": "https://doi.org/10.1002/cac2.12117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34236149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34236149"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Gao Liu, Tian Xiang, Quan-Feng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504015X14496932933575"}], "href": "https://doi.org/10.3727/096504015X14496932933575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26931432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26931432"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Tongtong Zou, Suraj K Jaladanki, Lan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01030-15"}], "href": "https://doi.org/10.1128/MCB.01030-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26884465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26884465"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yiping Huang, Yunfei Zheng, Chanyuan Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA H19 Inhibits Adipocyte Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Modulation of Histone Deacetylases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep28897"}], "href": "https://doi.org/10.1038/srep28897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27349231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27349231"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nan-Hyung Kim, Soo-Hyun Choi, Chang-Hyun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2013.478"}], "href": "https://doi.org/10.1038/jid.2013.478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24335901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24335901"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Selina Jessica Keppler, Francesca Gasparrini, Marianne Burbage, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2015.09.004"}], "href": "https://doi.org/10.1016/j.immuni.2015.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26453379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26453379"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yiqing Liu, Li Xu, Bingru Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA H19/microRNA-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2019.09.006"}], "href": "https://doi.org/10.1016/j.molimm.2019.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31574452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31574452"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "WenXing Fan, YunZhu Peng, Zhang Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A negative feedback loop of H19/miR-675/EGR1 is involved in diabetic nephropathy by downregulating the expression of the vitamin D receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28373"}], "href": "https://doi.org/10.1002/jcp.28373"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30815865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30815865"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yiping Huang, Yunfei Zheng, Lingfei Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA H19 Promotes Osteoblast Differentiation Via TGF-β1/Smad3/HDAC Signaling Pathway by Deriving miR-675."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2225"}], "href": "https://doi.org/10.1002/stem.2225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26417995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26417995"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Katarzyna A Dudek, Jérôme E Lafont, Aida Martinez-Sanchez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.111328"}], "href": "https://doi.org/10.1074/jbc.M110.111328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20529846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20529846"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wen-Long Gao, Ming Liu, Yanyan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/rna.20807"}], "href": "https://doi.org/10.4161/rna.20807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22832245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22832245"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Nizar Y Saad, Mustafa Al-Kharsan, Sara E Garwick-Coppens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27430-1"}], "href": "https://doi.org/10.1038/s41467-021-27430-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34880230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34880230"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xiao-Fei Shen, Yi Cheng, Qi-Rong Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.04.044"}], "href": "https://doi.org/10.1016/j.bbrc.2020.04.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32336544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32336544"}]}]}]}