{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence has underscored the role of non‐coding RNAs as key modulators of chemoresistance in cancer, with emerging data suggesting that MIR6751 may be an important regulatory player. In ovarian cancer cell models, treatment with triptolide has been shown to affect cisplatin resistance, an effect that appears to involve alterations in the expression of MIR6751, thereby potentially contributing to improved drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn parallel, investigations in lung cancer have revealed that circular RNAs—specifically circ_0002360—play significant roles in oncogenesis and chemoresistance. These studies propose that MIR6751 could interact within a broader non‐coding RNA network, influencing both tumor progression and the development of cisplatin resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nTogether, these findings converge to highlight MIR6751 as a potential mediator of chemotherapeutic response, acting through diverse molecular pathways in different cancer contexts. This integrative perspective not only advances our understanding of cisplatin resistance mechanisms but also unveils MIR6751 as a promising candidate for future biomarker development and targeted therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ruijuan Wang, Xiaoping Ma, Shan Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Triptolide antagonized the cisplatin resistance in human ovarian cancer cell line A2780/CP70 via hsa-mir-6751."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Med Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4155/fmc-2018-0108"}], "href": "https://doi.org/10.4155/fmc-2018-0108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29966441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29966441"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lingyan Ding, Lizhi Li, Zhaohui Tang "}, {"type": "b", "children": [{"type": "t", "text": "Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR-6751-3p to regulate the expression of ZNF300."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.14342"}], "href": "https://doi.org/10.1111/1759-7714.14342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35166026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35166026"}]}]}]}