{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence has revealed that hsa_miR-6756-5p functions as a pivotal post‐transcriptional regulator in penile mesenchymal cell development by modulating androgen receptor (AR) signaling. In normal physiology, the circular RNA hsa_circ_0000417 acts as a competing endogenous RNA (ceRNA), sequestering hsa_miR-6756-5p and thereby maintaining appropriate AR levels and ensuring the proper balance of cell proliferation and apoptosis via pathways such as PI3K/AKT. However, in hypospadias—a congenital malformation resulting from urethral closure failure—downregulation of hsa_circ_0000417 likely leads to increased availability of hsa_miR-6756-5p. This excess microRNA is then posited to dysregulate AR expression, ultimately perturbing downstream signaling cascades that control penile mesenchymal cell survival and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junqiang Huang, Cheng Su, Pingan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa_circ_0000417 downregulation suppresses androgen receptor expression and apoptotic signals in human foreskin fibroblasts via sponging miR-6756-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-023-08628-6"}], "href": "https://doi.org/10.1007/s11033-023-08628-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37389702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37389702"}]}]}]}