{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstracts do not describe or analyze a function for MIR6757. Instead, they focus on the roles of key transcription factors and regulatory pathways in organogenesis and cell-fate determination. For example, one abstract details how Gcm2 is essential in driving the terminal differentiation and survival of parathyroid cells after the initial establishment of the parathyroid domain in the common third pouch primordium"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while another shows that Gcm proteins (Gcm1 and Gcm2) facilitate the epigenetic activation of Hes5 expression to promote neural stem cell induction in early embryogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies extend this discussion by elucidating later developmental roles; one such report documents how MafB collaborates with Gcm2 to regulate PTH expression and proper parathyroid migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and another investigates how Shh signaling restricts the parathyroid marker Gcm2 to particular regions of the pharyngeal pouches."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In a separate work, the zinc-dependent DNA-binding activity of the GCM domain is characterized, adding mechanistic insights into the function of these transcriptional regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, investigations into the context-dependent activities of Foxn1 and Gcm2 in the thymus and parathyroid further underscore the importance of specific transcription factor landscapes in organ-specific fate choices."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, a study on long non-coding RNAs in breast cancer provides additional context on non-coding regulators in developmental and disease processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these studies offer a detailed view of the transcriptional and epigenetic networks that govern parathyroid, thymus, and neural development, none of them address or report on a function for MIR6757.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhijie Liu, Shannon Yu, Nancy R Manley "}, {"type": "b", "children": [{"type": "t", "text": "Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2007.02.014"}], "href": "https://doi.org/10.1016/j.ydbio.2007.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17382312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17382312"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seiji Hitoshi, Yugo Ishino, Akhilesh Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2875"}], "href": "https://doi.org/10.1038/nn.2875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21765423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21765423"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Akiyo Kamitani-Kawamoto, Michito Hamada, Takashi Moriguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.458"}], "href": "https://doi.org/10.1002/jbmr.458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21713993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21713993"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Armelle Grevellec, Anthony Graham, Abigail S Tucker "}, {"type": "b", "children": [{"type": "t", "text": "Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2011.02.012"}], "href": "https://doi.org/10.1016/j.ydbio.2011.02.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21349263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21349263"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Serge X Cohen, Martine Moulin, Oliver Schilling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The GCM domain is a Zn-coordinating DNA-binding domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)03257-x"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "03257-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12297286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12297286"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daisuke Nagakubo, Mayumi Hirakawa, Norimasa Iwanami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-17844-2"}], "href": "https://doi.org/10.1038/s41598-022-17844-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35941210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35941210"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xue Han, Fan Shi, Shujun Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC02086 promotes cell viability and inhibits cell apoptosis in breast cancer by sponging miR-6757-5p and up-regulating EPHA2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-023-03245-w"}], "href": "https://doi.org/10.1186/s12957-023-03245-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38008720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38008720"}]}]}]}