{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into cellular regulatory networks have revealed diverse roles for sorting nexins and long non‐coding RNAs in modulating signal transduction and cellular trafficking. While studies have characterized SNX6 functions in receptor trafficking, synaptic organization, bacterial infection, and nuclear envelope assembly"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ", a distinct regulatory circuit involving a microRNA has been elucidated in esophageal squamous cell carcinoma (ESCC).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn ESCC, the microRNA miR‑6759‑5p acts as a critical regulatory factor by targeting the insulin‐like growth factor 2 (IGF2). The oncogenic long non‐coding RNA lnc‑MCEI functions as a competing endogenous RNA by sponging miR‑6759‑5p, thereby diminishing its ability to suppress IGF2 expression. The resultant increase in IGF2 levels provokes activation of the PI3K/AKT signaling pathway, which in turn promotes cell proliferation, reduces apoptotic responses, and confers resistance to cisplatin chemotherapy. This finding highlights miR‑6759‑5p’s role as a tumor‐suppressive molecule whose inhibition by lnc‑MCEI contributes to ESCC chemoresistance and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megan E Cavet, Jinjiang Pang, Guoyong Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-094086"}], "href": "https://doi.org/10.1096/fj.07-094086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18523162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18523162"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Niu, Zhonghua Dai, Wenxue Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.20991"}], "href": "https://doi.org/10.7554/eLife.20991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28134614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28134614"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daryl Jason David, Alessandro Pagliuso, Lilliana Radoshevich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lmo1656 is a secreted virulence factor of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Listeria monocytogenes"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " that interacts with the sorting nexin 6-BAR complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.000365"}], "href": "https://doi.org/10.1074/jbc.RA117.000365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29666193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29666193"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jose M González-Granado, Ana Navarro-Puche, Pedro Molina-Sanchez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0115571"}], "href": "https://doi.org/10.1371/journal.pone.0115571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25535984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25535984"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guangming Liu, Wei Guo, Guang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.47051"}], "href": "https://doi.org/10.7150/ijbs.47051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33061807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33061807"}]}]}]}