{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into glioma biology have revealed that non-coding RNAs play pivotal roles in tumor progression. In one study, the circRNA hsa_circ_0076931 was found to be down-regulated in glioma tissues compared with normal brain tissues, and its expression was negatively correlated with tumor histological grade. Functionally, overexpression of hsa_circ_0076931 was shown to inhibit glioma cell proliferation, migration, and invasion while promoting apoptosis. A key mechanistic finding was that hsa_circ_0076931 acts as a molecular sponge for miR-6760-3p, thereby modulating downstream gene expression involved in tumor progression, such as increased CCBE1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, the silencing of miR-6760-3p via binding to hsa_circ_0076931 relieves its inhibitory effect on the target gene CCBE1. This interaction suggests that miR-6760-3p normally functions to suppress CCBE1 expression, a gene implicated in cancer-related pathways. Thus, by sequestering miR-6760-3p, hsa_circ_0076931 indirectly elevates CCBE1 levels, contributing to a less aggressive glioma phenotype through modulation of gene networks essential for tumor cell survival and motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe findings from this study highlight the potential of targeting the hsa_circ_0076931/miR-6760-3p/CCBE1 regulatory axis as a novel diagnostic and therapeutic strategy in glioma. By dampening miR-6760-3p activity, hsa_circ_0076931 may serve as a protective biomarker against malignant progression, emphasizing the critical contribution of non-coding RNA networks in the pathogenesis of brain tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanbin Ke, Shixing Su, Chuanzhi Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0076931 suppresses malignant biological properties, down-regulates miR-6760-3p through direct binding, and up-regulates CCBE1 in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20211895"}], "href": "https://doi.org/10.1042/BSR20211895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34931668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34931668"}]}]}]}