{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided abstracts reveals that none contain any mention or functional characterization of MIR6766. Instead, the collection of studies focuses on elucidating the roles of CDC25 family phosphatases—most notably CDC25B—in regulating cell cycle progression, meiotic resumption, mitotic entry, and related cellular checkpoints in diverse mammalian systems, including oocytes, embryonic cells, neural progenitors, and other tissues. This body of work provides detailed insights into how post‐translational modifications (such as phosphorylation at key residues) and interactions with regulatory proteins (for example, 14-3-3 isoforms, protein kinase A, and p38 MAPK) govern the activation of cyclin-dependent kinases like CDK1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSeveral of the abstracts detail how CDC25B serves as a key “starter” phosphatase that removes inhibitory phosphates from CDK1, thereby promoting entry into M phase during both meiotic and mitotic divisions. Experimental strategies—including gene disruption in mice, targeted point mutations, modulation of phosphorylation sites (e.g., Ser321, Ser229, Ser149), and manipulation of associated regulatory molecules—reveal that precise control of CDC25B localization and activity is central to cell cycle checkpoints, spindle organization, and overall cellular proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, while other signaling pathways—such as those involving sonic hedgehog, Foxm1, and 14-3-3 proteins—are explored for their contributions to cell fate decisions, spindle orientation, and progenitor production, none of these studies address or implicate MIR6766. Consequently, within the scope of this literature collection, MIR6766 does not have an assigned or characterized function, and its potential roles remain to be defined in contrast to the well-established mechanistic insights provided regarding CDC25 phosphatases and their regulatory networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Jeannine Lincoln, Dineli Wickramasinghe, Paula Stein, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.7.2853-2860.2005"}], "href": "https://doi.org/10.1128/MCB.25.7.2853-2860.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15767688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15767688"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bertrand Bénazéraf, Qiusheng Chen, Emilie Peco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.02.035"}], "href": "https://doi.org/10.1016/j.ydbio.2006.02.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16564519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16564519"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sneha Ramakrishna, Il-Man Kim, Vladimir Petrovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21113"}], "href": "https://doi.org/10.1002/dvdy.21113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17366632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17366632"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hyukjin Cha, Xuetao Wang, Henghong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional role for p38 MAPK in modulating mitotic transit in the absence of stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M700735200"}], "href": "https://doi.org/10.1074/jbc.M700735200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17548358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17548358"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gabriel D Dakubo, Shawn T Beug, Chantal J Mazerolle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2008.06.058"}], "href": "https://doi.org/10.1016/j.brainres.2008.06.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18625210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18625210"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cheng Cui, Hongmei Zhao, Zhe Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDC25B acts as a potential target of PRKACA in fertilized mouse eggs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.108.068205"}], "href": "https://doi.org/10.1095/biolreprod.108.068205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18633139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18633139"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yang Zhang, Zhe Zhang, Xiao-Yan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase A modulates Cdc25B activity during meiotic resumption of mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21799"}], "href": "https://doi.org/10.1002/dvdy.21799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19035343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19035343"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Giorgia Pirino, Melanie P Wescott, Peter J Donovan "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.8.4.7846"}], "href": "https://doi.org/10.4161/cc.8.4.7846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19223768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19223768"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Cheng Cui, Hao Tang, Bingzhi Yu "}, {"type": "b", "children": [{"type": "t", "text": "[Cdc25B overexpression reverses two-cell block in mouse embryos]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Ying Yong Sheng Li Xue Za Zhi (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21141569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21141569"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jianying Xiao, Chao Liu, Junjie Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ser149 is another potential PKA phosphorylation target of Cdc25B in G2/M transition of fertilized mouse eggs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.150524"}], "href": "https://doi.org/10.1074/jbc.M110.150524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21212267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21212267"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Gwanghee Lee, Sofia Origanti, Lynn S White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0015561"}], "href": "https://doi.org/10.1371/journal.pone.0015561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21283624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21283624"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ralph Gruber, Zhongwei Zhou, Mikhail Sukchev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2342"}], "href": "https://doi.org/10.1038/ncb2342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21947081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21947081"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jian-Ying Xiao, Chao Liu, Xiao-Han Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[PKA-regulated phosphorylation status of S149 and S321 sites of CDC25B inhibits mitosis of fertilized mouse eggs]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sheng Li Xue Bao (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22348958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22348958"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Petros Marangos, John Carroll "}, {"type": "b", "children": [{"type": "t", "text": "Oocytes progress beyond prophase in the presence of DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2012.03.063"}], "href": "https://doi.org/10.1016/j.cub.2012.03.063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22578416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22578416"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jun Meng, Cheng Cui, Yanchun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of 14-3-3ε interaction with phosphorylated Cdc25B at its Ser321 in the release of the mouse oocyte from prophase I arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0053633"}], "href": "https://doi.org/10.1371/journal.pone.0053633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23326474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23326474"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hyoeun Kang, Seok Cheol Hwang, Yong Seok Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdc25B phosphatase participates in maintaining metaphase II arrest in mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10059-013-0029-6"}], "href": "https://doi.org/10.1007/s10059-013-0029-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23661366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23661366"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Cheng Cui, Xiuli Ren, Dajun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3 epsilon prevents G2/M transition of fertilized mouse eggs by binding with CDC25B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Dev Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12861-014-0033-x"}], "href": "https://doi.org/10.1186/s12861-014-0033-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25059436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25059436"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jeesun Kim, Anup Kumar Singh, Yoko Takata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10116"}], "href": "https://doi.org/10.1038/ncomms10116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26626423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26626423"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Cheng Cui, Tianxia Zang, Yu Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDC25B is involved in the centrosomal microtubule nucleation in two-cell stage mouse embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Growth Differ (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/dgd.12328"}], "href": "https://doi.org/10.1111/dgd.12328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27885657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27885657"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Frédéric Bonnet, Angie Molina, Mélanie Roussat, et al. 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