{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe two studies provided focus on the roles of FLRT proteins in regulating cell adhesion, neuronal migration, and developmental signalling. In one study, deletion of FLRT1 and FLRT3 in mice was shown to reduce intercellular adhesion among cortical neurons, thereby enhancing their tangential migration and ultimately promoting cortical folding into sulci with maintained layered organization and radial glial morphology (a mechanism that may be relevant for understanding gyrification in humans). This work highlights the importance of adhesive interactions in brain morphogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nA complementary study examined the FLRT gene family during mouse development, revealing that FLRT proteins—with their extracellular leucine-rich repeats—mediate homophilic cell-cell adhesion and modulate fibroblast growth factor (FGF) signalling. FLRT3 was notably expressed in migrating muscle precursors and at critical embryonic boundaries, while all FLRTs were found capable of interacting with FGFR1. These findings illustrate how FLRT molecules contribute to both cell migration and the fine-tuning of growth factor signals during embryogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nDespite the detailed insights provided into FLRT-mediated processes, neither abstract addresses or mentions MIR6768. Therefore, based on these studies, no functional role for MIR6768 in either cortical folding or embryonic FGF signalling can be inferred. Future investigations will be required to determine whether MIR6768 interacts with these developmental pathways or fulfills distinct biological functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel Del Toro, Tobias Ruff, Erik Cederfjäll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2017.04.012"}], "href": "https://doi.org/10.1016/j.cell.2017.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28475893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28475893"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bryan P Haines, Lee M Wheldon, Dennis Summerbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.04.004"}], "href": "https://doi.org/10.1016/j.ydbio.2006.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16872596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16872596"}]}]}]}