{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-6775-3p functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC), where its high expression is linked to favorable clinical outcomes. The microRNA exerts its anti-tumor effects by inhibiting cell proliferation, migration, invasion, and by reducing tumor growth and liver metastasis in xenograft models. Mechanistically, miR-6775-3p achieves these effects by directly binding to the 3′ untranslated regions of mRNAs encoding members of the MAGE-A family, thereby reducing their expression and mitigating their inhibitory impact on the tumor suppressor p53. In parallel, miR-6775-3p also directly represses its host gene SLC7A5, which has oncogenic properties. Notably, p53 transcriptionally induces both miR-6775-3p and SLC7A5, creating a positive feedback loop that is critical for modulating ESCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lingjiao Meng, Fei Liu, Yingchao Ju, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-1119-3"}], "href": "https://doi.org/10.1038/s41419-018-1119-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30333480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30333480"}]}]}]}