{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer—a disease with a high mortality rate—the dysregulation of non‐coding RNAs, particularly circular RNAs (circRNAs), contributes significantly to tumor development and progression. Recent findings have revealed that the circRNA circSORBS1, which is notably underexpressed in lung cancer tissues, blood, and cell lines, functions by interacting with microRNAs. Specifically, circSORBS1 sequesters miR-6779-5p, thereby influencing downstream gene expression and contributing to the regulation of apoptosis and tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDisruption of the normal interaction between miR-6779-5p and its target mRNA is a critical aspect of this regulatory pathway. Under typical conditions, miR-6779-5p would promote the degradation of RUFY3 mRNA; however, circSORBS1 binds miR-6779-5p as a molecular sponge. This sequestration indirectly prevents RUFY3 mRNA degradation, while direct binding between circSORBS1 and RUFY3 mRNA further enhances its stability, resulting in elevated levels of RUFY3 protein."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nThe increase in RUFY3 protein subsequently activates the YWHAE/BAD/BCL2 apoptotic signalling pathway, thereby inhibiting lung cancer cell proliferation and migration while promoting apoptosis. This dual regulatory mechanism underscores the potential therapeutic value of targeting the circSORBS1/miR-6779-5p axis in lung cancer, as disrupting this finely tuned interaction can alter tumor progression and improve disease outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haotian Xu, Yue Zheng, Jiaxi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-024-05423-0"}], "href": "https://doi.org/10.1186/s12967-024-05423-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38915053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38915053"}]}]}]}