{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOvarian cancer metastasis is driven in part by ascites‐derived exosomes that transfer miR-6780b-5p to tumor cells, thereby accelerating epithelial-mesenchymal transition (EMT). Bioinformatics analysis and RNA sequencing data indicate that miR-6780b-5p is a critical regulator within these exosomes; its elevated expression correlates with increased metastatic potential in ovarian cancer patients. Overexpression of miR-6780b-5p enhances EMT, while its downregulation suppresses this process, emphasizing its pivotal role in promoting cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nMoreover, these findings suggest that the transfer of miR-6780b-5p via exosomes contributes significantly to the metastatic cascade, offering a potential molecular target for therapeutic intervention aimed at mitigating ovarian cancer spread."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Cai, Lanqing Gong, Guodong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes in ovarian cancer ascites promote epithelial-mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03490-5"}], "href": "https://doi.org/10.1038/s41419-021-03490-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33627627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33627627"}]}]}]}