{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requests a summary of MIR6790 function, none of the provided abstracts mention MIR6790. Instead, these studies consistently focus on the WD40 repeat-containing protein known as p44/WDR77, which plays a pivotal role in regulating cellular proliferation and differentiation during development as well as in tumorigenesis. For example, early during lung development, p44/WDR77 is expressed in rapidly growing epithelial cells, driving proliferation; however, its expression is lost upon terminal differentiation, with re‐expression being closely linked to lung cancer cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations reveal that p44/WDR77 functions as an essential cofactor for the androgen receptor (AR), modulating AR-dependent gene expression that is critical for prostate growth, differentiation, and even cell cycle re-entry in differentiated cells. Its subcellular localization is tightly controlled—shifting from the cytoplasm in proliferative stages to the nucleus in fully differentiated cells—with mislocalization associated with cancer progression. Additional studies indicate that transcriptional control of WDR77 involves regulatory switches mediated by E2F and GATA family members, reinforcing its role in preventing premature differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies extend the functional profile of WDR77 beyond developmental contexts. In bone, for instance, associations between related proteins (such as MEP50) and membrane receptors demonstrate its indirect role in cell maturation, while in antiviral immunity, WDR77 is shown to bind MAVS and inhibit its prion-like aggregation, thereby modulating RIG-I-MAVS signaling and subsequent innate immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Z Gu, F Zhang, Z-Q Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p44/wdr77-dependent cellular proliferation process during lung development is reactivated in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.207"}], "href": "https://doi.org/10.1038/onc.2012.207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22665061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22665061"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shen Gao, Hong Wu, Fen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered differentiation and proliferation of prostate epithelium in mice lacking the androgen receptor cofactor p44/WDR77."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2009-1080"}], "href": "https://doi.org/10.1210/en.2009-1080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20519372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20519372"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhongping Gu, Liran Zhou, Shen Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear transport signals control cellular localization and function of androgen receptor cofactor p44/WDR77."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0022395"}], "href": "https://doi.org/10.1371/journal.pone.0022395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21789256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21789256"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Deon O'Bryant, Zhengxin Wang "}, {"type": "b", "children": [{"type": "t", "text": "The essential role of WD repeat domain 77 in prostate tumor initiation induced by Pten loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0254-8"}], "href": "https://doi.org/10.1038/s41388-018-0254-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29706654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29706654"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liran Zhou, Keiko Hosohata, Shen Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0063119"}], "href": "https://doi.org/10.1371/journal.pone.0063119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23755100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23755100"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bryce Vincent, Hong Wu, Shen Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of the androgen receptor cofactor p44/WDR77 induces astrogliosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00298-12"}], "href": "https://doi.org/10.1128/MCB.00298-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22751923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22751923"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Min Yu, Ulrica Wang, Zhengxin Wang "}, {"type": "b", "children": [{"type": "t", "text": "E2F and GATA switches turn off WD repeat domain 77 expression in differentiating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20160130"}], "href": "https://doi.org/10.1042/BCJ20160130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27274086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27274086"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hyunsoo Kim, Matthew C Walsh, Jiyeon Yu, et al. 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