{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into pancreatic cancer have revealed that the long non-coding RNA LINC00930, which is significantly downregulated in pancreatic cancer tissues and cell lines, normally acts as a molecular “sponge” for miR-6792-3p. This microRNA binds directly to LINC00930, forming part of a regulatory axis that influences key tumor-related processes such as cell proliferation, metastasis, and epithelial–mesenchymal transition (EMT); notably, the decreased levels of LINC00930 correlate with enhanced aggressive cancer behavior and poorer patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExperimental evidence further demonstrates that the miR-6792-3p mimic can counteract the tumor-suppressing effects mediated by the downstream gene Zinc finger and BTB domain containing 16 (ZBTB16). By targeting and downregulating ZBTB16, miR-6792-3p effectively rescues the proliferation, metastasis, and EMT phenotypes in pancreatic cancer cells, underscoring its pivotal role in driving malignant progression. This axis not only highlights the functional importance of miR-6792-3p in pancreatic cancer pathogenesis but also identifies it as part of a potential prognostic and therapeutic target framework."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yingqing Mao, Xian Su, Qingsong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16 regulates the proliferation and EMT of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-024-12365-9"}], "href": "https://doi.org/10.1186/s12885-024-12365-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38789960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38789960"}]}]}]}