{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nExosomal miR-6803-5p has emerged as a key factor in colorectal cancer (CRC) progression, with studies demonstrating its significantly increased expression in the serum of CRC patients compared to healthy individuals. This dysregulation correlates with advanced TNM stages, lymph node metastasis, and liver metastasis, suggesting that miR-6803-5p actively participates in tumor advancement and dissemination. Elevated levels of this miRNA are also associated with markedly poorer overall survival (OS) and disease-free survival (DFS), underscoring its potential role as not only a marker of disease presence but also as a prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMultivariate Cox regression analyses have confirmed that the prognostic value of serum exosomal miR-6803-5p in CRC is independent of other clinical factors, reinforcing its utility as a robust diagnostic and prognostic biomarker. The delivery of miR-6803-5p via exosomes further highlights the intricate mechanisms of intercellular communication contributing to carcinogenesis and underscores novel avenues for therapeutic intervention in colorectal cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shushan Yan, Ye Jiang, Caihong Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-6803-5p as potential diagnostic and prognostic marker in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26609"}], "href": "https://doi.org/10.1002/jcb.26609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29240249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29240249"}]}]}]}