{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have shown that miR‑6807‑3p is markedly upregulated in glioma tissues, and this novel microRNA plays an oncogenic role by targeting the tumor suppressor gene DACH1. The dysregulation of miR‑6807‑3p in glioma cells has been linked to enhanced tumor progression, underscoring its importance in regulating key cellular processes in the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional investigations using RT‑qPCR, western blot, and luciferase reporter assays have demonstrated that miR‑6807‑3p directly binds to the 3′‑UTR of DACH1, thereby modulating its expression. As a result, increased miR‑6807‑3p levels promote cell proliferation, enhance migratory potential, inhibit apoptosis, and lessen cell cycle arrest in glioma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, the tumor‑promoting effects of miR‑6807‑3p are mitigated upon overexpression of DACH1, suggesting that the miR‑6807‑3p/DACH1 axis plays a critical role in glioma advancement and might represent a promising target for therapeutic intervention. The correlation between aberrant miR‑6807‑3p expression and clinical outcomes further highlights its potential clinical relevance in managing glioma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gui-Feng Lu, Fei Geng, Zhi Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-6807-3p promotes the tumorigenesis of glioma by targeting downstream DACH1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2018.12.008"}], "href": "https://doi.org/10.1016/j.brainres.2018.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30527681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30527681"}]}]}]}