{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations in pancreatic ductal adenocarcinoma (PDAC) have revealed that MIR6820 can function as a tumor suppressor through its regulation by competing endogenous RNAs. In particular, one study demonstrated that the circular RNA hsa_circ_0007367 is markedly upregulated in PDAC tissues and cells, where it acts as a molecular sponge for miR‐6820-3p. This sequestration of miR‐6820-3p results in the de-repression of the oncogene Yes-associated protein 1 (YAP1), thereby promoting cell proliferation and metastasis. These findings highlight the critical role of MIR6820 in maintaining oncogenic balance in PDAC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in esophageal squamous cell carcinoma (ESCC), a competing endogenous RNA (ceRNA) network has been described in which circSSPO binds to miR‐6820-5p. Under normal conditions, miR‐6820-5p is involved in the suppression of oncogenic targets such as kallikrein-related peptidase 8 (KLK8) and protein kinase D1 (PKD1). The downregulation of miR‐6820-5p by circSSPO leads to enhanced expression of these targets, thereby contributing to malignant cell properties including increased tumorigenic growth and metastasis in ESCC. This regulatory mechanism underscores the tumor suppressive potential of MIR6820 and its disruption in cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haocheng Zhang, Xiaolei Ma, Luning Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0007367 promotes the progression of pancreatic ductal adenocarcinoma by sponging miR-6820-3p and upregulating YAP1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05188-8"}], "href": "https://doi.org/10.1038/s41419-022-05188-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36008392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36008392"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qianhua Luo, Junzheng Li, Haixiong Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-023-09828-3"}], "href": "https://doi.org/10.1007/s10565-023-09828-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37812360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37812360"}]}]}]}