{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study detailed in the abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "characterizes an extracellular vesicle (EV)‐based pathway in which Listeria monocytogenes DNA is packaged into EVs by infected cells and subsequently delivered to bystander cells. This mechanism triggers the innate immune response via activation of the cGAS–STING pathway, leading to downstream effects that include inhibition of T‐cell proliferation and priming for apoptosis. In this context, the multivesicular body protein MVB12b, phosphorylated by TANK-binding kinase 1, is critical for sorting the bacterial DNA into EVs.\n \nNotably, despite the detailed elucidation of this immune‐modulatory pathway, the abstract does not provide any evidence regarding the function or involvement of MIR6823. Therefore, no functional role for MIR6823 is described or implied within the presented findings. As such, while the study sheds light on the mechanisms of EV‐mediated immune regulation during bacterial infection, the direct role of MIR6823 remains undetermined and awaits further investigation.\n \nGiven the lack of any mention of MIR6823 in the abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", its potential regulatory functions in either EV biogenesis, innate immune signaling, or T‐cell modulation during such infections are yet to be explored. Future studies are needed to clarify whether MIR6823 might contribute to these processes or modulate other aspects of the host immune response.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ramya Nandakumar, Roland Tschismarov, Felix Meissner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-019-0367-z"}], "href": "https://doi.org/10.1038/s41564-019-0367-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30804548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30804548"}]}]}]}