{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study designed to identify non‐invasive prognostic biomarkers for metastatic colorectal cancer vaccine therapy, plasma levels of miR‑6826 were investigated. In patients treated with a vaccine and possessing the HLA‑A*2402 genotype, high miR‑6826 expression was associated with a significantly poorer prognosis compared to patients showing low expression levels. This observation implies that miR‑6826 functions as a negative predictive biomarker, where elevated levels signal an inferior response to the immunotherapy regimen."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMultivariate analysis further underscored the importance of miR‑6826 by identifying its expression as the most significant predictor for overall survival in the treated patient cohort. These findings suggest that miR‑6826 may influence immune‐related signaling pathways that ultimately affect vaccine efficacy, and that its measurement in plasma could serve as a valuable tool for patient stratification and treatment planning."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Taiki Kijima, Shoichi Hazama, Ryouichi Tsunedomi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-6826 and -6875 in plasma are valuable non‑invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5267"}], "href": "https://doi.org/10.3892/or.2016.5267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878288"}]}]}]}