{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided abstracts does not reveal any functional information regarding MIR6832. None of the three publications mention or discuss MIR6832. Rather, they focus on the roles of mouse flavin‐containing monooxygenases (FMOs) in endogenous metabolism. In the first abstract, the authors describe how a deficiency of FMO1, along with FMO2 and FMO4, results in a lean phenotype characterized by reduced triglyceride storage and enhanced energy expenditure. This study highlights a novel regulatory role for FMO1 in energy homeostasis and establishes that FMOs can play important roles beyond xenobiotic metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe second abstract reports the cloning and expression of mouse FMO2. The study characterizes the enzymatic activity of FMO2—including its catalytic action toward substrates such as methimazole, thiourea, trimethylamine, and phorate—thereby adding to our understanding of FMO2’s contribution in metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe third abstract explores the protective role of FMO2 in kidney injury. It demonstrates that overexpression of FMO2 in a model of ischemia–reperfusion injury attenuates renal fibrosis and modulates TGF‑β–mediated signaling. These findings implicate FMO2 and its downstream mediator SMURF2 as key regulators in the transition of acute kidney injury to chronic kidney disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sunil Veeravalli, Bilal A Omar, Lyndsey Houseman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2014.04.007"}], "href": "https://doi.org/10.1016/j.bcp.2014.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24792439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24792439"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "E D Karoly, R L Rose "}, {"type": "b", "children": [{"type": "t", "text": "Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.10009"}], "href": "https://doi.org/10.1002/jbt.10009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11835629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11835629"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Longfei Wang, Hongchu Zha, Jing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2023.5313"}], "href": "https://doi.org/10.3892/ijmm.2023.5313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37800598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37800598"}]}]}]}