{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn Epstein–Barr virus (EBV)‐associated nasopharyngeal carcinoma, noncoding RNAs play a pivotal role in tumor progression. One study (39179085) demonstrated that the long noncoding RNA BC200 is significantly upregulated in EBV‐infected carcinoma cells and tissues, where it functions as a competing endogenous RNA (ceRNA). In this ceRNA network, BC200 acts by sponging and thereby inhibiting miR‑6834‑5p. miR‑6834‑5p normally targets thymidylate synthetase (TYMS), a gene that, when overexpressed, is associated with enhanced cellular proliferation and migration and poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe suppression of miR‑6834‑5p by BC200 results in the de-repression of TYMS, facilitating its abnormal upregulation in EBV‐positive NPC cells and tissues. This molecular interplay underscores the tumor‐suppressive role that miR‑6834‑5p is poised to play under normal conditions, and how its inhibition contributes to the oncogenic processes in nasopharyngeal carcinoma. Collectively, these findings suggest that the BC200/miR‑6834‑5p/TYMS axis is integral to NPC pathogenesis and may provide valuable biomarkers and potential targets for the diagnosis and treatment of EBV-associated cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Senmiao Zhang, Na Liu, Pengfei Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BC200 promotes the development of EBV-associated nasopharyngeal carcinoma by competitively binding to miR-6834-5p to upregulate TYMS expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2024.134837"}], "href": "https://doi.org/10.1016/j.ijbiomac.2024.134837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39179085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39179085"}]}]}]}