{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have begun to elucidate the emerging role of miR-6838-5p in tumor biology. In triple‐negative breast cancer (TNBC), although miR-6838-5p’s function has not yet been defined, its investigation is warranted to fill this critical gap in our understanding."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In gastric cancer, miR-6838-5p is notably downregulated, and restoration of its expression suppresses key malignant behaviors—including cell cycle progression, proliferation, migration, and invasion—by targeting GPRIN3 and consequently repressing the Wnt/β-catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond gastric cancer, miR-6838-5p has been implicated in other malignancies. In hepatocellular carcinoma, it is downregulated and functions as a tumor suppressor by targeting the epigenetic regulator CBX4, thereby modulating ERK signaling and attenuating the aggressive properties of liver cancer stem cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, its sequestration by the lncRNA CERS6-AS1 leads to dysregulation of downstream RUBCNL expression, which impacts cell proliferation, migration, and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in cervical cancer, miR-6838-5p is sponged by CERS6-AS1—resulting in enhanced expression of FOXP2 and consequent promotion of cell proliferation and invasion while inhibiting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, early evidence in breast cancer suggests that miR-6838-5p may regulate DDR1 gene expression, impacting cancer cell proliferation and offering a potential therapeutic target; however, more research is needed to fully delineate this role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guozhu Liu, Ping Wang, Hao Zhang "}, {"type": "b", "children": [{"type": "t", "text": "MiR-6838-5p suppresses cell metastasis and the EMT process in triple-negative breast cancer by targeting WNT3A to inhibit the Wnt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3129"}], "href": "https://doi.org/10.1002/jgm.3129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31693779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31693779"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weidong Zhou, Xiaoyun Ding, Peihua Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathobiology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000511691"}], "href": "https://doi.org/10.1159/000511691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33254176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33254176"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhimin Dou, Fei Lu, Jinjing Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2022-0156"}], "href": "https://doi.org/10.1515/hsz-2022-0156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36215729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36215729"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dong Chen, Huiming You, Xiaoping Xu, et al. 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