{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that TEAD4 plays a significant tumor‐promoting role in lung adenocarcinoma (LAD), being upregulated at both the mRNA and protein levels in tumor tissues compared to adjacent non-tumorous tissues. Functional analyses demonstrated that while TEAD4 silencing exerts minimal impact on cell cycle, proliferation, or apoptosis, it strikingly reduces cell migration and invasion, a process that correlates with changes in key epithelial-mesenchymal transition (EMT) markers such as E‐cadherin and Slug."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, a novel microRNA, miR6839-3p, was identified as a direct regulator of TEAD4. Overexpression of miR6839-3p mimics effectively suppressed TEAD4 expression and recapitulated the inhibitory effects of TEAD4 knockdown on tumor cell migration and invasion, highlighting its potential as a promising therapeutic approach in targeting LAD progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qun Zhang, Hang Fan, Qian Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TEAD4 exerts pro-metastatic effects and is negatively regulated by miR6839-3p in lung adenocarcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13634"}], "href": "https://doi.org/10.1111/jcmm.13634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29667772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29667772"}]}]}]}