{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have highlighted the role of neuron‐enriched microRNAs in the pathological accumulation of amyloid β‐peptide (Aβ), a central event in Alzheimer's disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this context, MIR6845 has emerged as a candidate regulator among several miRNAs that are aberrantly expressed in neuronal cell models, suggesting that it may influence molecular cascades triggered by Aβ‐induced cytotoxicity.\n \nAccumulation of Aβ is known to disrupt cellular homeostasis, and the systematic analysis of miRNA expression in SH-SY5Y cells exposed to Aβ has implicated miRNAs, including MIR6845, in modulating these toxic effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The data indicate that MIR6845 might be involved in fine-tuning the expression of target mRNAs that govern Aβ deposition or clearance mechanisms, thereby impacting neurodegenerative processes.\n\nThese findings support the hypothesis that MIR6845 functions as an important mediator in the response to Aβ stress by potentially regulating key signaling pathways and gene networks linked to neuronal survival and inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Further elucidation of its targets could not only deepen our understanding of Alzheimer's disease pathology but also offer new directions for therapeutic intervention.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ling Hu, Rong Zhang, Qiong Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25-35 triggered in SH-SY5Y cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Syst Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12918-018-0633-3"}], "href": "https://doi.org/10.1186/s12918-018-0633-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30547775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30547775"}]}]}]}