{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered that miR‐6848‐5p plays a critical role in the regulation of cataractogenesis by acting as an inhibitor of ALOX15. In a rat model of cataracts, a necroptosis‐related circular RNA, circRNA 06209, was found to be down‐regulated. Up‑regulation of circRNA 06209 acts as a molecular sponge that binds to miR‐6848‐5p, thereby curbing its inhibitory effect on ALOX15. This interaction alleviates the suppression of ALOX15, resulting in enhanced cell proliferation and reduced apoptosis, processes that are essential for inhibiting cataract development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese findings indicate that miR‐6848‐5p functions as a negative regulator in the context of lens cell survival, with its activity being modulated by circRNA 06209. The competitive binding between circRNA 06209 and miR‐6848‐5p not only highlights a novel regulatory mechanism in cataract pathology but also suggests that targeting this axis might offer a promising therapeutic strategy to mitigate cataract progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rui Fang, Jin-He Li, Hai-Long Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Eye Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exer.2023.109640"}], "href": "https://doi.org/10.1016/j.exer.2023.109640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37673368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37673368"}]}]}]}