{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough several of the provided abstracts deepen our understanding of RhoBTB3‐associated regulatory mechanisms in cancer and developmental processes, none of them report any findings related to MIR6849. In these studies, the focus is placed on aspects such as the role of circular RNAs in ovarian cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", the identification and characterization of substrates for RhoBTB–Cul3 ubiquitin ligase complexes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", detailed expression profiles and functional roles of RhoBTB3 during development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and its impact on platelet function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these investigations examine key regulatory pathways involving RhoBTB3 in contexts ranging from vesicle trafficking and proteasome-mediated degradation to cytoskeletal reorganization and tissue-specific development. However, none of the studies address or implicate MIR6849 in these events, leaving its functional role in these biological processes uncharacterized based on the current abstracts.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the cited publications significantly elaborate on the multifaceted roles of RhoBTB3 and its interacting partners, they do not provide any evidence regarding the function of MIR6849. As such, the current body of literature represented by these abstracts does not support a defined or characterized role for MIR6849.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yalan Sun, Yanfang Liu, He Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Panminerva Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.23736/S0031-0808.20.03957-9"}], "href": "https://doi.org/10.23736/S0031-0808.20.03957-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32720791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32720791"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kristína Schenková, Julia Lutz, Marion Kopp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2012.06.016"}], "href": "https://doi.org/10.1016/j.jmb.2012.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22709582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22709582"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Julia Lutz, Eva-Maria S Grimm-Günter, Pooja Joshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-014-1235-9"}], "href": "https://doi.org/10.1007/s00418-014-1235-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24923387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24923387"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Martin Berger, David R J Lutz, Julia Lutz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8020149"}], "href": "https://doi.org/10.3390/cells8020149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30754723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30754723"}]}]}]}