{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐6858 (miR-6858) has recently been identified as a critical mediator of cell fate in distinct pathologic contexts. In glioblastoma models, melatonin treatment induces a robust upregulation of miR-6858-5p that suppresses malignant behaviors by reducing cell viability, proliferation, migration, and invasion. Mechanistically, miR-6858-5p targets elements of the SIRT/AKT signaling pathway—most notably diminishing SIRT3 levels and subsequently altering downstream signaling events—to inhibit the aggressive phenotype of glioblastoma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, studies in oral lichen planus have revealed that enhanced N6-adenosine methylation (m6A) driven by NF-κB-mediated upregulation of METTL14 promotes the processing of primary miR-6858 transcripts, leading to increased miR-6858 production. Elevated miR-6858 in turn binds to the 3′ untranslated region of Gasdermin C (GSDMC) mRNA to promote its degradation, thereby triggering apoptosis in oral keratinocytes—a key feature in the pathogenesis of this chronic inflammatory disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chenglong Wang, Zhimin Zhao, Qichao Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-6858 plays a key role in the process of melatonin inhibition of the malignant biological behavior of glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jocn.2021.02.015"}], "href": "https://doi.org/10.1016/j.jocn.2021.02.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33863521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33863521"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiangyu Wang, Shuangting Li, Huimin Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-023-05360-6"}], "href": "https://doi.org/10.1038/s42003-023-05360-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37741915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37741915"}]}]}]}