{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings demonstrate that miR-6862, a novel microRNA residing in the cytoplasm of neuronal cells, plays a pivotal role in modulating neuronal survival by targeting SphK1 mRNA. Specifically, miR-6862 directly binds to the 3′-untranslated region of SphK1, reducing its expression when overexpressed in cell models such as SH-SY5Y and HCN-2. The downregulation of SphK1 resulting from elevated miR-6862 levels leads to heightened susceptibility of neurons to MPP+-induced apoptosis, a model of dopaminergic cell loss. Conversely, inhibition of miR-6862 elevates SphK1 expression and provides a protective effect against MPP+-mediated cytotoxicity, an effect that is nullified in SphK1-deficient cells. These results underscore miR-6862's critical function as a regulator of neuronal cell fate through its direct impact on SphK1 levels, thereby influencing the cellular response to neurotoxic insults."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gang Xue, Ju-Ping Chen, Ya Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-6862 inhibition elevates sphingosine kinase 1 and protects neuronal cells from MPP"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202335"}], "href": "https://doi.org/10.18632/aging.202335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33414358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33414358"}]}]}]}