{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have elucidated a critical role for miR‐6869‐5p in regulating cellular proliferation and invasion in cancer. In glioma, miR‐6869‐5p is significantly downregulated, a change that is associated with elevated levels of its target, PGK1. This loss of miR‐6869‐5p function facilitates increased tumor cell proliferation and invasiveness, and its diminished expression correlates with a poorer patient prognosis, highlighting its role as a tumor suppressor and promising prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disruptions in miR‐6869‐5p expression have also been implicated in the context of gestational diabetes mellitus, where its reduced levels in placenta‐derived mononuclear macrophages contribute to an imbalanced placental microenvironment. Specifically, miR‐6869‐5p directly targets PTPRO, and its downregulation promotes abnormal macrophage proliferation and a skewing away from the anti‐inflammatory M2 phenotype. This shift fosters a pro‐inflammatory milieu that may underlie adverse placental and immune outcomes in gestational diabetes mellitus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fakai Wang, Huanjun Zhang, Bing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/9752372"}], "href": "https://doi.org/10.1155/2020/9752372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32565733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32565733"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pingping Wang, Zhenzhi Ma, Zengyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6696636"}], "href": "https://doi.org/10.1155/2021/6696636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34007244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34007244"}]}]}]}