{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence suggests that the inactivation of Semaphorin 3B (SEMA3B), a gene known to be frequently silenced in various carcinomas, may have broader implications in gastric cardia adenocarcinoma (GCA) tumorigenesis through its associated transcripts. In particular, miR-6872—encoded within the SEMA3B locus—and the antisense lncRNA SEMA3B‐AS1 emerge as candidate regulators whose functions in GCA remain to be clarified. Although the precise mechanisms of miR-6872 are not yet defined, its genomic association with a tumor suppressor gene hints that it may influence critical cellular processes such as differentiation, proliferation, and apoptosis, either by fine-tuning SEMA3B expression or by modulating parallel pathways involved in carcinogenesis. Further functional studies are needed to delineate whether miR-6872 acts cooperatively with SEMA3B and SEMA3B‐AS1 to maintain tumor suppression or if its deregulation may promote oncogenic signaling in gastric tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Guo, Xiaoliang Liang, Lei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-6872 host gene SEMA3B and its antisense lncRNA SEMA3B-AS1 function synergistically to suppress gastric cardia adenocarcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastric Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10120-019-00924-0"}], "href": "https://doi.org/10.1007/s10120-019-00924-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30656427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30656427"}]}]}]}