{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn recent studies exploring the molecular regulators of endothelial dysfunction in atherosclerosis, MIR6873 has emerged as an important modulator through its interactions with circular RNAs. In one investigation, circ‐RELL1 was found to bind directly to MIR6873-3p in ox-LDL–induced human endothelial cells, thereby relieving the microRNA’s inhibitory effect on MyD88 protein expression. This sequestration facilitates NF-κB pathway activation and increases the expression of adhesion molecules such as ICAM1 and VCAM1, contributing to the proinflammatory state observed in atherosclerotic cardiovascular disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother study focusing on vascular disease identified that hsa_circ_0001879, a circular RNA upregulated in atherosclerosis patients, acts as a sponge for MIR6873-5p. In this context, the binding of MIR6873-5p by hsa_circ_0001879 prevents the microRNA from promoting the degradation of HDAC9 mRNA. This interruption of MIR6873-5p’s activity results in a decrease in endothelial cell proliferation and migration, suggesting that through targeting distinct mRNA substrates, MIR6873 contributes to the regulation of cellular processes central to vascular remodeling and lesion formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA related study examined the structure and cellular roles of sorting nexins, namely SNX20 and SNX21, in endosomal dynamics. Although this work provided novel insights into endosome-associated scaffolding and membrane trafficking, it did not address or implicate MIR6873 in its regulatory framework. This contrast underscores the context-dependent nature of MIR6873’s functions, which appear to be particularly critical in mediating inflammatory and proliferative responses in endothelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hua-Shan Huang, Xiao-Yan Huang, Hui-Zhen Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-κB axis in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.02.109"}], "href": "https://doi.org/10.1016/j.bbrc.2020.02.109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32113679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32113679"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feifei Li, Yahui Chen, Zhiling He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1997224"}], "href": "https://doi.org/10.1080/21655979.2021.1997224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34872444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34872444"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thomas Clairfeuille, Suzanne J Norwood, Xiaying Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.650598"}], "href": "https://doi.org/10.1074/jbc.M115.650598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25882846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25882846"}]}]}]}