{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence in osteosarcoma (OS) has demonstrated that miR-6874-3p functions as an important tumor suppressor. In OS tissues and cells, miR-6874-3p is notably underexpressed, and its low levels are associated with poorer patient overall survival. Conversely, overexpression of miR-6874-3p markedly inhibits OS cell proliferation, migration, and invasion, suggesting that this microRNA plays a pivotal role in hampering OS progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations further revealed that the long non-coding RNA ODRUL contributes to tumorigenesis by acting as a molecular sponge for miR-6874-3p. By sequestering miR-6874-3p, ODRUL prevents its suppressive function and indirectly leads to the upregulation of IL-6, a cytokine implicated in OS progression. This regulatory axis between ODRUL, miR-6874-3p, and IL-6 provides valuable insights into the molecular underpinnings of OS and offers potential avenues for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Taicheng Zhan, Kunpeng Zhu, Jianping Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ODRUL regulates progression of osteosarcoma by regulating IL-6 via sponging miR-6874-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2022.113050"}], "href": "https://doi.org/10.1016/j.yexcr.2022.113050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35114192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35114192"}]}]}]}