{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies in hepatocellular carcinoma have begun to explore the role of MIR6875, with one investigation specifically analyzing the miR‐6875-3p isoform. Although its precise function has yet to be fully elucidated, preliminary data suggest that miR‐6875-3p may be involved in the regulation of cellular mechanisms related to tumor occurrence, proliferation, invasion, and metastasis in this cancer type."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of vaccine treatment for metastatic colorectal cancer, another line of research has associated elevated plasma levels of MIR6875 with a poorer prognosis. In this setting, increased expression of miR‐6875 correlates with reduced vaccine efficacy, positioning it as a potential non‐invasive biomarker to predict negative treatment outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther extending its clinical relevance, investigations into recurrent spontaneous abortion have identified that enhanced expression of the miR‐6875-5p isoform disrupts immune regulation by directly targeting the STAT3/E2-2 signaling pathway. This interaction impedes the differentiation of plasmacytoid dendritic cells, a process critical for successful fetal–maternal immunotolerance, thereby suggesting that aberrant MIR6875 levels may contribute to the pathogenesis of spontaneous abortion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yingjun Xie, Jian Du, Zefeng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-6875-3p promotes the proliferation, invasion and metastasis of hepatocellular carcinoma via BTG2/FAK/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-1020-z"}], "href": "https://doi.org/10.1186/s13046-018-1020-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30621734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30621734"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Taiki Kijima, Shoichi Hazama, Ryouichi Tsunedomi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-6826 and -6875 in plasma are valuable non‑invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5267"}], "href": "https://doi.org/10.3892/or.2016.5267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878288"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiao-Xiao Zhu, Xun-Qiang Yin, Guo-Zhen Hei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased miR-6875-5p inhibits plasmacytoid dendritic cell differentiation via the STAT3/E2-2 pathway in recurrent spontaneous abortion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gaab044"}], "href": "https://doi.org/10.1093/molehr/gaab044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34240166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34240166"}]}]}]}