{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-6883-5p—an intronic microRNA encoded within the clock gene PER1—plays a critical role in colorectal cancer by targeting the 3′ untranslated regions of CDK4 and CDK6 mRNAs. This targeting results in the downregulation of these key cell-cycle regulators, contributing to a significant inhibition of tumor cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nEctopic expression of miR-6883-5p in colorectal cancer cells induces a robust G0-G1 phase cell-cycle arrest and triggers apoptosis. Although CDK4/6 downregulation is an important mechanism underlying these anti-proliferative effects, additional pathways are likely involved in mediating its full spectrum of tumor suppressor capabilities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nMoreover, miR-6883-5p demonstrates a synergistic effect when combined with conventional chemotherapy—specifically, it enhances the efficacy of irinotecan and re-sensitizes mutant p53-expressing cell lines that are resistant to 5-fluorouracil. These findings underscore the promise of miR-6883-5p as a candidate for developing miRNA-based theranostic strategies to improve colorectal cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amriti R Lulla, Michael J Slifker, Yan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-6883 Family miRNAs Target CDK4/6 to Induce G"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "1"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " Phase Cell-Cycle Arrest in Colon Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-1767"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-1767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29061672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29061672"}]}]}]}