{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn severe preeclampsia, a critical regulatory network involved in endometrial decidualization and glycolysis is disrupted. Specifically, the long noncoding RNA HK2P1 and its associated gene HK2 play indispensable roles in maintaining proper decidualization, with HK2 being a key enzyme in glycolysis. Notably, HK2P1 modulates HK2 expression by competitively binding to miR-6887-3p, thereby acting as a molecular sponge. This ceRNA mechanism ensures optimal glucose uptake and lactate production essential for endometrial stromal cell proliferation and differentiation, and its downregulation may contribute to the development of preeclampsia by impairing glycolytic flux and decidualization processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate study investigating the mechanism of RNA-binding proteins in colorectal cancer, Mex3a was examined for its role in tumorigenesis and clinical progression. Although this work did not directly address miR-6887, it underscores the broader impact of RNA-mediated regulatory pathways in disease and opens avenues that may intersect with microRNA functions like those of miR-6887 in other cellular contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother investigation focused on macrophage energy metabolism and inflammation demonstrated the significance of metabolic enzymes, such as adenylate kinase 4 (Ak4), in modulating inflammatory gene expression and reactive oxygen species production in M1 macrophages. While this study did not explore miR-6887 directly, its findings contribute to the growing body of literature that links energy homeostasis and RNA-regulated gene expression to inflammatory responses, further highlighting the complex interplay by which microRNAs may influence cellular metabolism and immune activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong Lv, Jing Tong, Jieqiong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated Pseudogene "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HK2P1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " May Contribute to Preeclampsia as a Competing Endogenous RNA for Hexokinase 2 by Impairing Decidualization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.117.10084"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.117.10084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29440331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29440331"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haixia Li, Jinghui Liang, Jiang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Commun (Lond) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cac2.12149"}], "href": "https://doi.org/10.1002/cac2.12149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33638620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33638620"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei-Yao Chin, Chi-Ying He, Tsun Wai Chow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenylate Kinase 4 Promotes Inflammatory Gene Expression "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Hif1α and AMPK in Macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.630318"}], "href": "https://doi.org/10.3389/fimmu.2021.630318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33790902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33790902"}]}]}]}