{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into primary Sjögren’s syndrome (pSS) have revealed that miR6891‐5p—a microRNA expressed from the HLA locus—is essential for maintaining balanced X‐chromosome gene expression in mesenchymal stromal cells. In healthy female cells, X‐linked genes are expressed from both parental alleles; however, in pSS, decreased levels of miR6891‐5p correlate with disrupted XIST regulation and reorganization of H3K27me3 marks, leading to preferential expression (allelic skewing) from one X chromosome and mislocalization of its encoded proteins. Functional inhibition of miR6891‐5p in control cells recapitulates these abnormalities, underscoring its critical role in ensuring proper epigenetic control and X‐chromosome inactivation dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile the study of intrahepatic cholestasis of pregnancy (ICP) has expanded our understanding of adverse pregnancy outcomes, the specific involvement of miR6891 in ICP was not addressed, suggesting that its regulatory functions may be context‐dependent and warrant further investigation across diverse pathological conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Teressa M Shaw, Wei Zhang, Sara S McCoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren's syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-022-02205-3"}], "href": "https://doi.org/10.1007/s00109-022-02205-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35538149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35538149"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ningzhen Ye, Xinrui Shi, Jianyi Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-023-08265-w"}], "href": "https://doi.org/10.1007/s10620-023-08265-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38361148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38361148"}]}]}]}