MIR6893 Gene

HGNC Family Non-coding RNAs
Name microRNA 6893
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCervical cancer remains one of the most prevalent malignancies affecting women globally. Recent studies have highlighted the regulatory potential of circular RNAs such as circMTO1 in the context of the disease; however, the detailed molecular mechanisms involved, including any potential role for MIR6893, have not been fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPreliminary insights suggest that non‐coding RNAs may interact within complex regulatory networks influencing tumorigenesis. In this framework, MIR6893 is posited as a candidate that could participate, either directly or indirectly, in the circMTO1-mediated modulation of cervical cancer progression. Its function may involve the fine‐tuning of gene expression and interference with signaling pathways critical to cellular proliferation and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite this potential, comprehensive functional characterization of MIR6893 in cervical cancer remains sparse. Further experimental investigation is necessary to delineate its precise role and to understand how its interaction with circMTO1 may influence disease pathology. Such studies could ultimately provide new avenues for targeted therapeutic strategies in cervical cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mengmeng Chen, Guihai Ai, Jianhong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109064"}], "href": "https://doi.org/10.1016/j.biopha.2019.109064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31226633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31226633"}]}]}]}
Synonyms HSA-MIR-6893
NCBI Gene ID 102466271
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Predicted Functions View MIR6893's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR6893's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR6893's ARCHS4 Predicted Functions.

Functional Associations

MIR6893 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.

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Dataset Summary