{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that a conserved regulator—commonly referred to as Mon1a (previously known as SAND‐1 in nematodes)—plays a critical role in the trafficking of key cellular proteins. In iron‐recycling macrophages, Mon1a is required for efficient delivery of ferroportin, the major iron exporter, to the cell surface. This regulatory step directly influences cellular iron content and overall iron homeostasis, while genetic variations in Mon1a and its interplay with other iron‐regulatory proteins contribute to the heterogeneity observed in iron disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther work has highlighted the role of the Mon1a–Ccz1 complex in ensuring proper clearance of apoptotic cells. Acting as a critical link in the progression of phagosomal maturation, Mon1a associates with GTP‐bound Rab5 and promotes a transition to Rab7‐positive phagosomes. This Rab conversion is essential for the progression of internalized apoptotic corpses along the degradative pathway, thus safeguarding tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in iron metabolism and apoptotic cell clearance, Mon1a also contributes broadly to vesicular traffic within the secretory pathway. It is involved in multiple trafficking steps, including transport from the endoplasmic reticulum to the Golgi apparatus and subsequent Golgi reformation. Reduced levels of Mon1a lead to delayed vesicle formation and altered Golgi morphology, underlining its importance in maintaining efficient intracellular protein transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fudi Wang, Prasad N Paradkar, Angel O Custodio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng2059"}], "href": "https://doi.org/10.1038/ng2059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17632513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17632513"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Constance Delaby, Vincent Oustric, Caroline Schmitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-013-9479-6"}], "href": "https://doi.org/10.1007/s00335-013-9479-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24121729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24121729"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jason M Kinchen, Kodi S Ravichandran "}, {"type": "b", "children": [{"type": "t", "text": "Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08853"}], "href": "https://doi.org/10.1038/nature08853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20305638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20305638"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dustin C Bagley, Prasad N Paradkar, Jerry Kaplan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mon1a protein acts in trafficking through the secretory apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.354043"}], "href": "https://doi.org/10.1074/jbc.M112.354043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22665492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22665492"}]}]}]}