| HGNC Family | Non-coding RNAs |
| Name | microRNA 7-1 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐7 (miR‑7–1) is emerging as a pivotal regulator in cancer, acting mainly as a tumor suppressor yet sometimes displaying context‐dependent oncogenic features. In several malignancies—including glioblastoma, head and neck carcinomas, tongue squamous cell carcinoma, melanoma, gastric, renal, ovarian, prostate, colorectal and non‐small cell lung cancers—miR‑7–1 suppresses cell proliferation, invasion and metastasis by directly targeting key oncogenes such as the epidermal growth factor receptor (EGFR), p21‐activated kinase 1 (Pak1), insulin‐like growth factor 1 receptor (IGF1R), IRS‑2, CCNE1 and the stemness regulator KLF4. By inactivating downstream pathways (PI3K/Akt, Raf/MEK/ERK and NF‑κB) and by interfering with epithelial–mesenchymal transition processes, its down‐regulation is frequently associated with drug resistance and aggressive tumor behavior. Moreover, miR‑7–1 is subject to multifaceted regulation: its activity is attenuated by “sponging” via circular RNAs (e.g., CDR1as/ciRS‑7) and is also modulated by upstream transcription factors (such as HoxD10) as well as by inflammatory signals that impact Toll‑like receptor signaling and autophagy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncology, miR‑7–1 plays critical roles in the endocrine system and neuronal homeostasis. During pancreas development, miR‑7–1 is highly enriched in islets where it regulates endocrine cell differentiation, insulin granule exocytosis and β‑cell proliferation—processes that are key for maintaining glucose‐stimulated insulin secretion and proper metabolic adaptation in obesity and type 2 diabetes. In neuronal models, miR‑7–1 confers cytoprotection by targeting mitochondrial proteins such as VDAC1, thereby reducing oxidative stress and preserving mitochondrial integrity. Furthermore, by modulating both chemoresistance and radiosensitivity through interference with survival and autophagic pathways, miR‑7–1 has been shown to restore the sensitivity of drug‐ and radio‑resistant tumor cells. Collectively, these multifaceted roles underscore the therapeutic potential of miR‑7–1 across a spectrum of disorders ranging from cancer to metabolic and neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benjamin Kefas, Jakub Godlewski, Laurey Comeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-6639"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-6639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18483236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18483236"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sirigiri Divijendra Natha Reddy, Kazufumi Ohshiro, Suresh K Rayala, et al. 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| Synonyms | MIR-7-1, MIRN7-1, HSA-MIR-7-1 |
| NCBI Gene ID | 407043 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR7-1 has 1,118 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.
Click the + buttons to view associations for MIR7-1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR7-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR7-1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR7-1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR7-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR7-1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR7-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR7-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MIR7-1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MIR7-1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MIR7-1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR7-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MIR7-1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with MIR7-1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR7-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR7-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR7-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR7-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR7-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |