{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR7-3HG, the host gene for miR-7, plays multifaceted roles in cellular homeostasis. In neuronal cells, miR-7 derived from MIR7-3HG represses Keap1 expression via its 3′UTR, thereby enhancing Nrf2‐mediated antioxidant responses to counteract oxidative stress. In hepatocellular carcinoma, miR-7 suppresses the expression of VDAC1, resulting in reduced cell proliferation, migration, and invasion, while in vascular endothelial cells, miR-7 directly targets KLF4 to downregulate VEGF and inhibit angiogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these roles, MIR7-3HG functions as a potent anti-autophagic regulator. Specifically, miR-7 processed from MIR7-3HG targets the 3′UTR of AMBRA1 mRNA, leading to decreased AMBRA1 mRNA and protein levels. This action blocks autophagy and, by preventing MYC dephosphorylation, establishes a positive feedback loop that further enhances its own transcription, thereby implicating MIR7-3HG in oncogenic regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, a novel aspect of MIR7-3HG function has emerged in pancreatic β-cells, where a short peptide encoded by this long noncoding RNA modulates dexamethasone-induced β-cell dysfunction. This discovery underscores the dual functional capacity of MIR7-3HG to act not only through miR-7 mediated post-transcriptional regulation but also via the production of bioactive peptides that may contribute to glucocorticoid-induced metabolic disturbances."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Savan Kabaria, Doo Chul Choi, Amrita Datta Chaudhuri, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4912"}], "href": "https://doi.org/10.3892/or.2016.4912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27431648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27431648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mariacristina Capizzi, Flavie Strappazzon, Valentina Cianfanelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2016.1269989"}], "href": "https://doi.org/10.1080/15548627.2016.1269989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28059583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28059583"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoming Mao, Jinliang Zhou, Limin Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.01.004"}], "href": "https://doi.org/10.1016/j.bbrc.2023.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36731335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36731335"}]}]}]}