MIR708 Gene

HGNC Family Non-coding RNAs
Name microRNA 708
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐708 has emerged as a key regulatory molecule in cancer, acting largely as a tumor suppressor. In renal cell carcinoma, its restored expression reduced cell viability and invasion through direct repression of critical survival proteins such as survivin, ZEB2, and BMI1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In prostate cancer, low levels of miR‐708 correlate with an expansion of the CD44+ tumor‐initiating cell population, where re‐expression of the miRNA targets CD44 and AKT2 to decrease tumorigenicity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in metastatic breast cancer, miR‐708 is transcriptionally repressed by polycomb-mediated H3K27 trimethylation, and its enforced expression suppresses metastasis by downregulating neuronatin and thereby reducing intracellular calcium signalling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, in chronic lymphocytic leukemia (CLL) miR‐708 is epigenetically silenced by enhancer hypermethylation, leading to derepression of IKKβ and activation of NF‐κB signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while its downregulation in hepatocellular carcinoma has been noted."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its general tumor suppressive activities, miR‐708 exerts its effects through specific targets in various tumor types. In non‐small cell lung cancer, miR‐708-5p inhibits cancer stem cell-like properties by directly suppressing DNMT3A, leading to increased expression of the tumor suppressor CDH1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In breast cancer, additional studies demonstrate that miR‐708 can downregulate LSD1 to curb proliferation and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and in another report, miR‐708-3p was shown to inhibit epithelial-to-mesenchymal transition by targeting key EMT activators such as ZEB1, N-cadherin, and vimentin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In triple-negative breast cancer, nanoparticle-mediated delivery of miR‐708 preferentially targets a SOX2/OCT4-marked subpopulation with high metastatic potential"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", whereas in glioma, miR‐708 overexpression suppresses proliferation and invasion via inhibition of SPHK2 and its downstream AKT/β-catenin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In contrast, miR‐708-5p appears to play an oncogenic role in pancreatic ductal adenocarcinoma by targeting SIRT3, thereby promoting proliferative and invasive phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Moreover, in breast cancer stem cells, miR‐708 directly binds to CD47 to enhance macrophage-mediated phagocytosis and impair self-renewal."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOutside of the classical oncologic scenarios, miR‐708 is also implicated in non-malignant pathologies. In mesenchymal stem cells derived from patients with steroid-induced osteonecrosis of the femoral head, miR‐708 is upregulated by glucocorticoids and suppresses osteogenic as well as adipogenic differentiation by directly targeting SMAD3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In the context of psychiatric disorders, lower circulating levels of miR‐708 in bipolar disorder patients during depressive episodes have been observed, suggesting its potential as a biomarker for disease state."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Preliminary investigations in osteosarcoma propose a role for miR‐708 in modulating cellular behavior although its precise functions require further clarification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, in liver fibrosis, miR‐708 directly targets the 3′-UTR of TMEM88, leading to enhanced hepatic stellate cell activation and extracellular matrix accumulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Collectively, these studies underscore the multifaceted roles of miR‐708 across different biological contexts, serving as a promising diagnostic marker and therapeutic target in both cancer and other disease states.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sharanjot Saini, Soichiro Yamamura, Shahana Majid, et al. 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Synonyms HSA-MIR-708, MIRN708
NCBI Gene ID 100126333
API
Download Associations
Predicted Functions View MIR708's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR708's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR708's ARCHS4 Predicted Functions.

Functional Associations

MIR708 has 543 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for MIR708 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR708 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR708 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR708 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR708 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR708 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR708 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR708 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR708 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR708 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR708 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR708 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of MIR708 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR708 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR708 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR708 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR708 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.