{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR7109 functions as a key post‐transcriptional regulator in cancer immunity by directly targeting the mRNA of Siglec‐15, a molecule implicated in tumor immune suppression. In clear‐cell renal cell carcinoma, the long non‐coding RNA LINC00973 upregulates Siglec‐15 expression through a competitive endogenous RNA (ceRNA) mechanism that sequesters MIR7109, thereby alleviating its inhibitory effect on Siglec‐15. This regulatory interplay not only alters the cell surface abundance of Siglec‐15 but also modulates immune activation, as evidenced by its antagonistic impact on co‐cultured T cells. In summary, under normal conditions, MIR7109 acts to repress Siglec‐15 expression, and its sponging by LINC00973 contributes to immune evasion in the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanbin Liu, Xingzhi Li, Changming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14611"}], "href": "https://doi.org/10.1111/cas.14611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32780490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32780490"}]}]}]}