MIR711 Gene

HGNC Family Non-coding RNAs
Name microRNA 711
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR‐711 as a multifunctional microRNA whose dysregulation contributes to oncogenesis and altered cellular communication. In gastric cancer cells, miR‐711 functions in a tumor suppressor capacity: one report showed that upregulation of miR‐711 by RASSF1A leads to downregulation of CDK4 expression, resulting in G1 cell cycle arrest"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while another study demonstrated that restoration of miR‐711 expression inhibits cell invasion, migration, and epithelial–mesenchymal transition through downregulation of CD44 along with modulation of vimentin and E‐cadherin levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the setting of viral malignancies, miR‐711 has been implicated in HIV‐1 and Kaposi's sarcoma‐associated herpesvirus co‐infection. Here, HIV‐1 Vpr upregulates miR‐711, which directly targets the 3′ untranslated region of Notch1 mRNA. The consequent suppression of Notch signaling diminishes IκBα expression, thereby activating NF‐κB and promoting the expression of pro‐proliferative as well as survival cytokines, an axis that favors the establishment of KSHV latency."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, miR‐711 is also transferred via exosomes in leukemia, where K562 cell‐derived exosomal miR‐711 is delivered to bone marrow mesenchymal stem cells. Once internalized, miR‐711 downregulates the adhesion molecule CD44, leading to reduced adhesion capacity of these stromal cells—a mechanism that may contribute to the impaired bone marrow microenvironment observed in chronic myelogenous leukemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aijun Liao, Gao Tan, Lin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF1A inhibits gastric cancer cell proliferation by miR-711- mediated downregulation of CDK4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6813"}], "href": "https://doi.org/10.18632/oncotarget.6813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26735582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26735582"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei-Sheng Xiao, De-Feng Li, Ya-Ping Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6681"}], "href": "https://doi.org/10.3892/or.2018.6681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30226620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30226620"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qin Yan, Runran Zhao, Chenyou Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of MicroRNA 711 Mediates HIV-1 Vpr Promotion of Kaposi's Sarcoma-Associated Herpesvirus Latency and Induction of Pro-proliferation and Pro-survival Cytokines by Targeting the Notch/NF-κB-Signaling Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00580-18"}], "href": "https://doi.org/10.1128/JVI.00580-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29976660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29976660"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yu-Huan Jiang, Jing Liu, Jin Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.10.096"}], "href": "https://doi.org/10.1016/j.bbrc.2019.10.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31677790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31677790"}]}]}]}
Synonyms HSA-MIR-711
NCBI Gene ID 100313843
API
Download Associations
Predicted Functions View MIR711's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR711's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR711's ARCHS4 Predicted Functions.

Functional Associations

MIR711 has 764 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR711 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR711 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR711 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR711 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR711 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR711 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR711 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR711 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR711 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of MIR711 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR711 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR711 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR711 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR711 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR711 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR711 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.