{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings exploring the signaling pathways in peripheral blood mononuclear cells (PBMCs) from individuals with posttraumatic stress disorder (PTSD) have highlighted general defects that could underlie the chronic peripheral inflammation seen in these patients. Although the study (1) did not explicitly mention MIR7113, this microRNA is a member of a class of small regulatory RNAs known to modulate gene expression and, thereby, can potentially influence key immune signaling processes. By regulating the translation or stability of mRNAs encoding proteins involved in inflammatory cascades, MIR7113 may contribute to either aberrant activation or impaired resolution of immune responses, a mechanism that is consistent with the dysregulated pathways observed in PTSD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disrupted regulation of signaling molecules suggests that microRNAs play an important upstream role in fine-tuning immune responses. Given that chronic inflammation in PTSD may arise from failures in these regulatory systems, MIR7113 could represent one of the molecular switches that, when misregulated, lead to persistent immune system activation. Its function, as inferred from the context of altered PBMC signaling, may involve the suppression or enhancement of critical signaling intermediates that determine the intensity and duration of inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Further studies that directly examine MIR7113’s targets and its regulatory network in immune cells are necessary to elucidate its precise role in the pathophysiology of PTSD. Clarifying whether MIR7113 acts as a pivotal mediator in the cascade leading to chronic inflammation could open new avenues for targeted therapeutic strategies aimed at correcting immune dysfunction and mitigating the lasting inflammatory burden in affected individuals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marpe Bam, Xiaoming Yang, Brandon P Busbee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-020-00238-3"}], "href": "https://doi.org/10.1186/s10020-020-00238-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33189141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33189141"}]}]}]}