| HGNC Family | Non-coding RNAs |
| Name | microRNA 7152 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "details the identification of Mp11, an evolutionarily conserved glycoprotein that is a novel component of peripheral myelin. In vertebrates, the myelin sheath is essential for rapid salutatory conduction and proper neuronal function, and Mp11 appears to play a critical role in this process by reinforcing the structural integrity of peripheral nerve myelin.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMp11 expression is directly regulated by the transcription factor Egr2, which is known to induce a suite of fundamental myelin-associated genes during normal development and remyelination after nerve injury. The study demonstrates that, similar to other Egr2-dependent genes, Mp11 is strictly controlled in its expression levels and is localized specifically to regions within the myelin, such as the Schmidt-Lanterman incisures and paranodes, where it is requisite for proper myelination.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that the abstract does not provide any information regarding MIR7152. While the original query asks for a summary of MIR7152 function, the available abstract exclusively characterizes Mp11. Thus, based on the provided source, no functional details or roles for MIR7152 in myelination or other cellular processes can be inferred. (PMID:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elizabeth J Ryu, Mao Yang, Jason A Gustin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1659-08.2008"}], "href": "https://doi.org/10.1523/JNEUROSCI.1659-08.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18650334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18650334"}]}]}]}
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| Synonyms | HSA-MIR-7152 |
| NCBI Gene ID | 102465689 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR7152 has 0 functional associations with biological entities spanning 0 categories () extracted from 0 datasets.
Click the + buttons to view associations for MIR7152 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary |
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