{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "characterizes TMEM190, a small transmembrane protein with a trefoil domain that is specifically expressed in the testis and incorporated into sperm. Although the provided abstract does not mention MIR7154, if one is seeking insights into a similarly named regulatory RNA, note that the abstract focuses on TMEM190. In mouse sperm, TMEM190 is translated into a 19‐kDa protein that localizes to the inner acrosomal membrane in cauda epididymal sperm and translocates to the equatorial segment—a key site for sperm–oocyte fusion—during the acrosome reaction. Its colocalization with IZUMO1, an immunoglobulin‐like protein essential for gamete fusion, suggests that TMEM190 is part of a multiprotein complex that may indirectly facilitate the fusion process, although genetic deletion of Tmem190 in mice does not impair fertility, indicating a non‐essential or redundant role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hitoshi Nishimura, Surabhi Gupta, Diana G Myles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reproduction (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/REP-10-0391"}], "href": "https://doi.org/10.1530/REP-10-0391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21273369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21273369"}]}]}]}