{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-7156-3p plays a critical tumor‐suppressive role in malignant glioma. In glioma tissues, the expression of miR-7156-3p is markedly decreased relative to normal brain tissue, and this downregulation correlates closely with higher tumor grade and poorer patient survival. In cell culture and animal models, reduced miR-7156-3p levels promote glioma cell stemness, invasiveness, and growth, whereas increased levels result in an inhibitory effect on these malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nFurthermore, mechanistic investigations have identified Homeobox D13 (HOXD13) as a direct target of miR-7156-3p. The suppression of HOXD13 by miR-7156-3p is crucial for modulating the oncogenic behaviors observed in glioma cells. Experimental approaches, including luciferase reporter assays and cell transfection techniques, have substantiated this regulatory relationship, thereby highlighting a novel pathway contributing to glioma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nThese findings not only enhance our understanding of glioma biology but also suggest that miR-7156-3p may serve both as a promising biomarker for disease progression and a potential therapeutic target for anti-glioma treatment strategies. The ability of miR-7156-3p to curb glioma cell stemness and invasiveness by targeting HOXD13 underscores its significance in the development of future clinical interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junfeng Zhang, Mengsheng Deng, Haipeng Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel miR-7156-3p-HOXD13 axis modulates glioma progression by regulating tumor cell stemness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.51293"}], "href": "https://doi.org/10.7150/ijbs.51293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33162825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33162825"}]}]}]}