{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA-7160 (miR-7160) acts as a potent tumor suppressor in non‐small cell lung cancer (NSCLC) by directly targeting the mRNA of SIX1, a homeoprotein whose upregulation is closely associated with NSCLC tumorigenesis and progression. Binding of miR-7160 to SIX1 mRNA decreases its expression, which in turn leads to the inhibition of cancer cell growth, proliferation, migration, and invasion, while promoting apoptosis. Notably, blockade of miR-7160 results in elevated SIX1 levels and enhanced oncogenic activity, and the restoration of SIX1 expression negates the anti-tumor effects induced by miR-7160. In vivo, intratumoral administration of a miR-7160-expressing lentivirus culminated in reduced SIX1 mRNA levels and suppressed NSCLC xenograft growth, a finding that is further corroborated by the observed inverse correlation between miR-7160 and SIX1 expression in human NSCLC specimens."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hua-Si Zhao, Xiao-Min Tao, Qun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing SIX1 by miR-7160 inhibits non-small cell lung cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202398"}], "href": "https://doi.org/10.18632/aging.202398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33686961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33686961"}]}]}]}