{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-718 plays a critical role in modulating tumor progression by directly controlling key mediators of cell growth and angiogenesis. In ovarian cancer, for example, miR-718 is expressed at low levels and inversely correlates with vascular endothelial growth factor (VEGF). Restoration of miR-718 expression directly represses VEGF levels and reduces downstream phospho‐AKT signaling, thereby inhibiting tumor proliferation both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of hepatocellular carcinoma (HCC), evidence indicates that miR-718 functions within a regulatory network that promotes malignant behavior. Two independent studies demonstrate that in HCC, elevated levels of miR-718 lead to downregulation of the tumor suppressor PTEN. One study showed that miR-718 overexpression was associated with enhanced cellular proliferation and poorer survival, while another established an inverse relationship between the long non-coding RNA SEMA3B-AS1 and miR-718, with miR-718 dampening PTEN expression and further promoting cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, investigations in papillary thyroid and gastric cancers support the oncogenic activity of miR-718. In papillary thyroid cancer, miR-718 has been implicated in increasing cell malignancy, whereas in gastric cancer, its upregulation not only correlates with reduced PTEN expression but also enhances phosphatidylinositide 3-kinase/protein kinase B (PI3K/Akt) signaling, leading to increased proliferation and invasion. Together, these findings suggest that miR-718 exerts context-dependent effects that contribute significantly to tumorigenesis by modulating critical signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ruobing Leng, Lang Zha, Liangdan Tang "}, {"type": "b", "children": [{"type": "t", "text": "MiR-718 represses VEGF and inhibits ovarian cancer cell progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2014.04.040"}], "href": "https://doi.org/10.1016/j.febslet.2014.04.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24815691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24815691"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhong-Dong Wang, Fan-Yong Qu, Yuan-Yuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Zhejiang Univ Sci B (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1631/jzus.B1600205"}], "href": "https://doi.org/10.1631/jzus.B1600205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28070994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28070994"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuchuan Zhong, Yan Li, Tao Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00019.2019"}], "href": "https://doi.org/10.1152/physiolgenomics.00019.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31251699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31251699"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiuyan Wang, Ming Qi "}, {"type": "b", "children": [{"type": "t", "text": "miR-718 is involved in malignancy of papillary thyroid cancer through repression of PDPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2018.08.022"}], "href": "https://doi.org/10.1016/j.prp.2018.08.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30166214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30166214"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shufang Liu, Ying Tian, Chanchan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.909527"}], "href": "https://doi.org/10.12659/MSM.909527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30131483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30131483"}]}]}]}