{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have shown that miR-7515 functions as a tumor suppressor in non‐small cell lung cancer. In one investigation, miR-7515 was found to directly target cell division cycle 20 (CDC20), a key regulator that is overexpressed in NSCLC tissues and associated with poor patient prognosis. Downregulation of CDC20 by miR-7515 led to diminished cell proliferation, migration, and invasion, as well as enhanced apoptosis, underscoring its potential as a therapeutic target in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a related study on epithelial ovarian cancer, miR-7515 was revealed to play a critical anti-tumor role through a different molecular mechanism. Here, the oncogenic long noncoding RNA FTX acts as a sponge for miR-7515, thereby relieving its suppression of tumor protein D52 (TPD52). Restoration of miR-7515 levels resulted in downregulation of TPD52 and subsequent inactivation of the Met/Akt/mTOR signaling pathway, which in turn reversed epithelial-mesenchymal transition and decreased cell viability, migration, and invasion. These findings further consolidate the notion that miR-7515 exerts tumor suppressive effects across diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hao Hu, Fang-Fang Tou, Wei-Min Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1321 and microRNA-7515 contribute to the progression of non-small cell lung cancer by targeting CDC20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12500"}], "href": "https://doi.org/10.1002/kjm2.12500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35050556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35050556"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yong Li, Xinghua Zhu, Can Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-620"}], "href": "https://doi.org/10.14670/HH-18-620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37140169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37140169"}]}]}]}