{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‐758 (including its isoforms miR‐758‐3p and miR‐758‐5p) plays multifaceted roles in regulating both metabolic/differentiation processes and tumorigenesis. In the realm of metabolic regulation, miR‐758‐5p has been shown to reduce cholesterol accumulation in macrophage‐derived foam cells by directly targeting the scavenger receptor CD36, thereby modulating cholesterol uptake and offering promise for atherosclerotic vascular disease therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, during osteogenic differentiation of periodontal ligament stem cells, miR‐758 is modulated by the long noncoding RNA ANCR and directly targets Notch2, contributing to the regulation of osteoblast differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancers, miR‐758 generally acts as a tumor suppressor by negatively regulating oncogenic signaling pathways. In hepatocellular carcinoma, up‐regulation of miR‐758‐3p suppresses cell proliferation, migration, and invasion through its direct inhibition of targets such as MDM2 and mTOR."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In non‐small cell lung cancer, reduced miR‐758‐3p—as mediated by the oncogenic lncRNA DANCR—leads to increased malignant potential, whereas restoration of miR‐758‐3p directly targeting NUSAP1 inhibits cellular proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Further, in papillary thyroid cancer, miR‐758‐3p exerts antitumor effects by directly targeting TAB1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in esophageal cancer, hypoxia‐induced downregulation of miR‐758‐3p—as part of a lncRNA EMS/miR‐758‐3p/WTAP axis—contributes to chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In glioblastoma, miR‐758‐5p has been implicated in tumor regulation via suppression of ZBTB20"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while in breast cancer, competitive binding of the circular RNA hsa_circ_0069094 to miR‐758‐3p leads to de‐repression of oncogenes such as DCUN1D1, thereby promoting proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the context‐dependent versatility of miR‐758, which modulates key molecular targets across diverse biological systems—from regulating cholesterol metabolism and osteogenic differentiation to suppressing tumor growth and metastasis. Such multifunctionality not only highlights miR‐758’s potential as a biomarker for varied disease states but also suggests that therapeutic strategies aimed at restoring or modulating its expression may benefit conditions ranging from atherosclerosis to multiple malignancies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bi-Rong Li, Lin-Qin Xia, Jing Liu, et al. 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